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Endocrine Abstracts

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ea0081p615 | Diabetes, Obesity, Metabolism and Nutrition | ECE2022

Is age-related hepatic elevation of endogenous SERM 27-hydroxycholesterol associated with hepatocellular degeneration female-specific? − Results from Rat study

S.ošić-Jurjević Branka , Jovanović Ljubiša , Marina Ljiljana , Ristic Natasa , Miler Marko , Ajdžanović Vladimir , Filipović Branko , Luetjohann Dieter

The cholesterol oxidation product 27-hydroxycholesterol (27OHC) is enzymatically produced from cholesterol by CYP27A1 in an alternative pathway of cholesterol degradation to bile acids. This oxysterol also acts as an endogenous selective estrogen receptor modulator (SERM). In healthy humans its concentration in circulation increases in hypercholesterolemia and with age, and is associated with increased risk of atherosclerosis, cardiovascular diseases and breast cancer. Several...
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Endocrine Abstracts
ISSN 1470-3947 (print) | ISSN 1479-6848 (online)
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